Serious affections of the brain quickly followed; many fell into a state of violent feverish delirium[692], and these generally died[693]. All complained of obscure _pain in the head_[694]; and it was not long before an alarming _lethargy_ supervened[695], which, if it was not firmly resisted, led to inevitable death by apoplexy. Thus the unconscious sufferers were, at least, relieved from the pain of separation from their friends, which would have been much more distressing to them in this than in any other complaint, since they lay, as it were, in a stinking swamp, tortured with suffering. This mortal anguish accompanied them so long as they were in possession of their senses, throughout the whole disease[696]. _In many the countenance was bloated and livid_, or at least the lips and cavities of the eyes were of a leaden tint; whence it evidently appears, that the passage of the blood through the lungs was obstructed in the same way as in violent asthma[697]; _hence they breathed with great difficulty_, as if their lungs were seized with a violent spasm or incipient paralysis; at the same time, _the heart trembled and palpitated_ constantly under the oppressive feeling of inward burning, which, in the most malignant cases, flew to the head, and excited fatal delirium[698]. In the course of a short time, and in many cases at the very commencement, the _stinking sweat_ broke out in streams over the whole body, either proving salutary when life was able to obtain the mastery over the disease, or prejudicial when it was subdued by it—as is the case in every ineffectual effort of nature to produce a cure. And in this respect, as in diseases of less importance, great differences appeared according to the constitution of the patient; for some perspired very easily, others, on the contrary, with great difficulty, especially the phlegmatic, who, in consequence, were threatened with the greatest danger[699]. In this severe struggle the _spinal marrow_ was sometimes, at a later stage, so much affected, that even _convulsions_ came on; and it happened not unfrequently, that, in consequence of the constriction of the chest, the stomach indicated its excited condition by _nausea_ and _vomiting_[700]. These symptoms, however, manifested themselves principally in those who were attacked with the disease upon a full stomach.