MIGNONETTE.—Cascara sagrada is a comparatively new drug. It is a liquid extract made from the bark of _Rhamnus Purshiana_ by maceration in water and alcohol. Syrup of buckthorn is a country preparation of the bark of _Rhamnus Frangula_. It is far less efficacious than cascara. The dose of cascara sagrada is from one-half to two teaspoonfuls. It is a useful aperient in many cases. AFFLICTED.—We published an article on blushing and nervousness a short time back. Of course your heart may be diseased; but remember that very many diseases of the heart are not very serious, and if care be taken, do not in any way interfere with or limit life. There is only one form of valvular disease of the heart which ever kills suddenly. This is aortic regurgitation—a form of disease very uncommonly due to rheumatism. INQUIRER.—The public must be getting rather tired of nostrums guaranteed to “cure all diseases of the stomach, bowels, liver and kidneys.” The fact that there are some hundreds of patent preparations sold to cure everything is sufficient to prove that the “elixir of life” still remains undiscovered. That any drug will ever be discovered that will cure every disease, even of one organ, is hardly conceivable. We cannot understand how any agent could cure two diametrically opposite conditions. Do you think that millions would die of diseases of the stomach, liver and kidneys, if a cure for them could be obtained for 1s. 1½d. per bottle—cure guaranteed after taking two bottles—that is, for 2s. 3d.? OLIVE MARY.—1. A few weeks ago we gave a _résumé_ of the treatment of indigestion such as you suffer from. If you read this column carefully, you cannot help finding many dozens or hundreds of answers concerning diet and digestion.—2. You will find the following very useful:—five drops of essence of ginger, and ten drops of compound tincture of cardamons in a wineglassful of water. This may be taken occasionally as required. Do not take it regularly, and leave it off as soon as you can. You will soon get the upper hand of your indigestion if you carry out our instructions carefully. MATER.—Knock-knees are very common. They are almost invariably caused by rickets in childhood. The treatment for the condition varies with its severity. If very severe an operation may be required to straighten the legs. If slight, the deformity may often be cured by splints. FROM A MALE READER.—There is nothing known which will remove hair or prevent it from growing. When we say nothing, we mean nothing which is in any way possible in your case. You can lighten the colour of your hair and so make it less noticeable with peroxide of hydrogen.