The important bearing of anaphylaxis on clinical practice is obvious. With therapeutic sera accidents have been fairly common in the past, grave effects following a second injection; this is a pure anaphylactic phenomenon. Much research has been done to find out methods of preventing the anaphylactic shock, and the most important advances in the field of anti-anaphylaxis are due to Dr. Besredka. His book naturally devotes much space to this aspect of the study, and gives details of the successful technique which he has developed. He worked mainly on guinea-pigs, having obtained extreme regularity of reaction with these animals. His most important result, both from the theoretical and the practical standpoint, is that vaccination against anaphylaxis can be produced by a system of gradually increasing doses, starting with the injection of a very small amount of the substance in question. This has led to a routine for serum injection by graduated doses, which has been successful in averting serum sickness. Besredka's interpretation of his results is against Richet's theory that the second injection combines with a substance, the toxogenin, present in the serum as a consequence of the first injection, and so produces a poison, the apotoxin. He considers rather that the reaction of the injected substance, the antigen, with the substance already formed (which he calls sensibilisin) itself produces the fatal result by disturbing the equilibrium of certain nerve cells where the combination takes place. By graduating the doses the reaction is watered down into a series of slight shocks, so that the great shock produced by a single injection is spread over a comparatively large time, and becomes innocuous. He finds an analogy between the effect and the mixing of water and sulphuric acid. If the water is poured in quickly there is an explosive action, but if it is added gradually the combination takes place without violence. "In our opinion the anaphylactic poison does not exist." There are a great number of interesting experiments cited in the book which we cannot mention here. The translator has done his work well, although we do not like some of his importations from the French. It should not be impossible to find expression more English than "titre of toxicity" and "fulminating cases." He has added an excellent chapter on "Recent Work on Anaphylaxis." We are glad to see at last a short work in English on the subject, which is one of the most fascinating fields in modern medicine. Somebody should translate and bring up to date Richet's excellent little book. It is a pity that the nomenclature of the subject cannot be made uniform. THE NEW TEACHING SERIES OF PRACTICAL TEXT-BOOKS: APPLIED BOTANY. By G. S. M. ELLIS. FOUNDATIONS OF ENGINEERING. By W. H. SPIKES. CHEMISTRY FROM THE INDUSTRIAL STANDPOINT. By P. C. L. THORNE. Hodder & Stoughton. 4_s._ 6_d._ net each.