Protoplasm, when quiescent, is, broadly speaking, solid; but when it is disturbed in an appropriate way, or sometimes even spontaneously without external disturbance, it becomes, broadly speaking, liquid. A moner in this state is seen under the microscope to have streams within its matter; a slime-mould slowly flows by force of gravity. The liquefaction starts from the point of disturbance and spreads through the mass. This spreading, however, is not uniform in all directions; on the contrary it takes at one time one course, at another another, through the homogeneous mass, in a manner that seems a little mysterious. The cause of disturbance being removed, these motions gradually (with higher kinds of protoplasm, quickly) cease, and the slime returns to its solid condition. The liquefaction of protoplasm is accompanied by a mechanical phenomenon. Namely, some kinds exhibit a tendency to draw themselves up into a globular form. This happens particularly with the contents of muscle-cells. The prevalent opinion, founded on some of the most exquisite experimental investigations that the history of science can show, is undoubtedly that the contraction of muscle-cells is due to osmotic pressure; and it must be allowed that that is a factor in producing the effect. But it does not seem to me that it satisfactorily accounts even for the phenomena of muscular contraction; and besides, even naked slimes often draw up in the same way. In this case, we seem to recognise an increase of the surface-tension. In some cases, too, the reverse action takes place, extraordinary pseudopodia being put forth, as if the surface-tension were diminished in spots. Indeed, such a slime always has a sort of skin, due no doubt to surface-tension, and this seems to give way at the point where a pseudopodium is put forth. Long-continued or frequently repeated liquefaction of the protoplasm results in an obstinate retention of the solid state, which we call fatigue. On the other hand repose in this state, if not too much prolonged, restores the liquefiability. These are both important functions.