In parts structurally weak at birth the bloodvessels, because of thin and weak walls, are larger than in normal parts, and because of dilatation the blood circulates slower. There is an undue pressure upon all between-vessel structures, a pressure that must lessen the nutrient supply more or less, according to its degree. The death of parts in boils and abscesses is due, I believe, to strangulation of the nerve-supply. The bloodvessels are elastic, and capable of contraction and dilatation, a matter regulated by the brain. Now in these weaknesses always lie the possibilities of disease; they may be supposed the weak links in the constitutional chain, and can no more be made stronger than the constitutional design than can the body as a whole. By whatever means brain power is lessened abnormality is incited in the weak parts; hence gradually from the original weakness there is a summing up, as a bronchial or nasal catarrh, or other acute or chronic local or general disease. The first step in any disease is the impression that lessens brain power; the slightest depressing emotion, the slightest sense of discomfort, lessens brain power, and to a like degree the tone of all the bloodvessels; hence dilatation in degree. That the stomach, as the most abused organ of the body, plays the largest part in over-drafts upon the brain is not a matter of doubt. Let us develop a chronic disease along these lines, with nasal catarrh for an illustration. As tone is regulated entirely by the brain system, all taxing of the brain increases the debility of the nasal structures. In course of time the debility so increases through whatever also debilitates the brain, that a stage is reached when water in the blood begins to escape through the thin walls of the vessels and mingles with the natural secretion of the membrane, and a catarrhal discharge is the result. In severe cases a time may be reached when death of parts from the strangling pressure may occur, and then we have an ulcerative catarrh. This evolution will go on as determined by the gravity of the ancestral weakness, by the natural strength of the dynamo, the brain, and the severity of the debilitating forces to which it may be subjected. No one is ever attacked by a nasal or any other catarrh, nor by any other chronic ailings. They all start from structural weaknesses that are inherited, and they are the evolutionary results of brain-wearying forces.