The pathology of influenzaWinternitz, M. C. (Milton C.)
Science
The pathology of influenza
Winternitz, M. C. (Milton C.)
Influenza
Pneumococcus Type II was recovered from the blood, pleural fluid,
and lung. B. influenzæ was also demonstrated in the lung by smears
and cultures.
In contrast to this example of a very diffuse, organizing pneumonia,
associated with a marked peribronchial organization where the illness
lasted for three weeks with hardly a remission throughout its course,
the following example of necrotizing and organizing lobar pneumonia may
be considered.
_Autopsy No. 183._
A white male, aged 46 years, was admitted to the New Haven Hospital
on January 9, 1919, complaining of “pneumonia.” The family history
was unimportant. He stated that he was in the hospital twelve years
ago with typhoid fever and again five years ago with acute
cholecystitis.
His present illness began two weeks previous to admission with
chills, fever, anorexia, nausea, vomiting, and a slightly productive
cough. He was prostrated and drowsy, but could not sleep. On
admission his temperature was 101.5°F., the pulse 124, and the
respirations 34 per minute. He was cyanotic and dyspnœic. The right
chest showed signs of consolidation, and fluid below the 3rd
interspace. The white blood count was 8,200 cells per cubic
millimeter, 89% being polymorphonuclear leucocytes. The patient died
eighteen hours after admission.
The autopsy was held four hours after death and the essential
findings were as follows:—
Twelve hundred cubic centimeters of fibrinopurulent fluid were found
in the right pleural cavity and the visceral and parietal pleura had
a thick, yellow coat of fibrin. The right lung was voluminous,
retained its shape on removal, and weighed 1,800 grams. The lower
two lobes were consolidated and the upper lobe was atelectatic. On
section the latter was slightly congested, but not consolidated. The
lower two lobes were fairly smooth and grey, mixed with red areas,
and exuded thick, sanguinous pus. They also showed several necrotic
areas in the central portion and, in some instances, cavities 1
centimeter in diameter filled with sanguinous pus had formed. The
bronchi contained the same material, and on its removal a deep red
mucosa was exposed. The left lung showed some fibrous pleurisy over
its lateral, posterior, and diaphragmatic surfaces. There was a
firm, puckered scar at the apex. The lung crepitated throughout, and
on section was essentially normal except for moderately intense
injection of the bronchi. The hilic nodes were enlarged, soft,
succulent, moderately injected, and pigmented. The trachea was pale,
but was covered by a mucopurulent exudate. The right side of the
heart was moderately dilated. The spleen was not enlarged, but was
softened and congested. The liver was pale, slightly decreased in
consistency, and congested. The kidneys and adrenals showed cloudy
swelling. The gall-bladder contained several stones, had a thickened
wall, and was bound to the pylorus by firm, fibrous adhesions.
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