The pathology of influenzaWinternitz, M. C. (Milton C.)
Science
The pathology of influenza
Winternitz, M. C. (Milton C.)
Influenza
Microscopic examination of the lung showed the alveoli filled with
an acute inflammatory exudate in many stages of degeneration and
hyalinization (Fig. XLII). Abscesses were frequent, but were for the
most part small. A similar necrotic mass was contained in the
bronchi. There were, however, features of the microscopic picture
that outweighed those already described. The alveolar and
bronchiolar exudates were everywhere being invaded by a young
granulation tissue, rich in fibroblasts and capillaries. Mononuclear
cells abounded in the new tissue. Even more striking than the
mesodermal new growth was the epithelial proliferation which could
be seen in many areas. It not only attempted to cover the denuded
bronchial surfaces, but stretched over masses of exudate and
granulation in the lumina and extended in tongue-like projections
for a considerable distance into the surrounding lung tissue (Fig.
XLVIII).
[Illustration:
FIG. XXVII. AUTOPSY NO. 115. HERE THE HEMORRHAGIC CONSOLIDATION
INVOLVES THE DEPENDENT PORTION OF THE LUNG; CONTRAST THIS WITH THE
EDEMATOUS AND EMPHYSEMATOUS UPPER LOBE.
]
[Illustration:
FIG. XXVIII. AUTOPSY NO. 118. THE CONSOLIDATION IS GREY IN COLOR AND
LOBAR IN TYPE. IN THE CENTER OF THE HEPATIZED LOBE THERE IS A
LARGE HEMORRHAGE. THE UPPER LOBE IS CONGESTED AND EDEMATOUS.
]
Cultures of the blood, lung, and pleural fluid showed gram-positive,
bile insoluble diplococci which formed chains, and morphologically
and culturally were Streptococcus mucosus capsulatus.
These two examples differ widely in the distribution of the pulmonary
involvement. They show the acute inflammatory process persisting and
complicating the attempt at repair, which manifests itself, not only by
the formation of granulation tissue, but also by extensive epithelial
proliferation.
Still a third type of chronic lesion is manifested in Autopsy No. 209,
where the necrotizing and organizing process in the pulmonary parenchyma
is associated with typical saccular bronchiectatic cavities.
_Autopsy No. 209._
A white woman, aged 55 years, was admitted to the New Haven Hospital
complaining of weakness and ill health following pleurisy. For the
past seventeen years she had suffered from a gradually progressing
arthritis, which had resulted in marked deformity and disability.
Five weeks before admission she became ill with chills, fever,
cough, and pain on both sides of the chest. Thereafter, her general
condition had gradually grown worse.
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