The pathology of influenzaWinternitz, M. C. (Milton C.)
Science
The pathology of influenza
Winternitz, M. C. (Milton C.)
Influenza
The physical examination showed a well developed and well nourished
male, who was slightly jaundiced and markedly prostrated. The
conjunctivæ were injected. The heart, abdomen, extremities, and
right lung were negative. In a small area outside the left nipple
and extending into the axilla, tubular breathing and subcrepitant
râles were heard, but no definite signs of consolidation were made
out. The physical signs remained the same during the eight-day stay
in the hospital. At entrance his temperature was 102.8°F. In twelve
hours it fell to 100°F., then rose to 103°F., where it stayed for
twenty-four hours, falling by lysis and remaining normal for the
three last days. On his eighth day in the hospital, the patient
suddenly collapsed and died within fifteen minutes.
The autopsy was held one hour after death and the essential findings
were as follows:—
The peritoneal cavity contained 100 cubic centimeters of clear,
straw-colored fluid and the viscera, particularly the liver, were
acutely congested. The right side of the heart was greatly dilated;
and on opening the pulmonary artery _in situ_ considerable blood
gushed forth under pressure and a huge, tortuous embolus completely
filled the vessel and its branches (Fig. LIII). The veins of the
vesicoprostatic plexus on the right, and the right internal and
external iliac veins contained thrombi, and it was evidently from
this region that the embolus had been set free. The pleura of the
lower third of the left lung over an oval area about 13 × 5
centimeters was bound to the parietal pleura by pinkish-grey,
translucent adhesions which were evidently of comparatively recent
origin. Here the lung was firmly consolidated, but it was apparently
normal elsewhere. On section the consolidated area was silvery grey,
with a pink tinge, comparatively dry and smooth. In some areas,
especially about the bronchi, delicate, silvery grey, translucent
strands could be seen sweeping out into the surrounding lung, which
contained no air. The remainder of the lung was air-containing. The
trachea showed moderate congestion most marked near the bifurcation.
The hilic lymph nodes were enlarged, soft, congested, and succulent,
as well as anthracotic.
[Illustration:
FIG. XXIX. THE VESSELS OF THE ALVEOLAR WALLS ARE CONGESTED AND
CONTAIN A LARGE NUMBER OF LEUCOCYTES. THE EXUDATE IS COMPOSED
ALMOST ENTIRELY OF WHITE BLOOD CELLS, IN THE BODIES OF WHICH
INNUMERABLE BACTERIA MAY BE SEEN. COMPARE FIGURES XXI, AND XXXII.
]
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