[4] Rouhier, _Monographie_, 196, 201, 205, 212. [5] Henry (T. A.), _The Plant Alkaloids_, 194-95; Moureu, _Review_, 520; Heffter, _Ueber zwei Cacteenalkaloïde_, 2976; _Ueber Pellote_, 69-73; Späth, _Ueber die Anhalonium_; I, _Anhalin und Mezcalin_, 129, 138-39; II, _Die Konstitution_, 97, 263. Anhalonine has been found in _A. jourdanianum_ (Henry, _op. cit._, 194; Heffter, _Ueber Pellote_, 427) which is identical with _Lophophora_. See Heffter, _Ueber zwei Cacteenalkaloïde_, 2976-77, also vols. 29:216, 223-25, 227; 34:3005, 3008, 3013; Heffter and Capellman, _Versuch zur Synthese_, 38:3634-40; Kauder, _Über Alkaloide_, 190-98. Späth, with Gangl and Röder, _Über de Anhalonium_, IV, VI; Kunkel, _Handbuch_, 836. APPENDIX 6: PHYSIOLOGY OF PEYOTE ACTION OF THE INDIVIDUAL ALKALOIDS OF LOPHOPHORA WILLIAMSII Since the alkaloids of peyote fall into two classes with regard to physiological action, the strychnine-like (increased reflex-irritability to the point of tetanus) and the morphine-like (sedative-soporific) and since there are important ethnographic considerations concerning the supposed “sex” of peyote, we discuss the action of each alkaloid before characterizing pan-peyotl physiologically. The two groups are somewhat antagonistic in action; ethnographic indications seem to point to the earlier action of the strychnine-like alkaloids, and a delayed reaction of the morphine-like. However, the size of the dose and the continued ingestion of buttons during the night cause variations in the length of the different periods of intoxication. The peyote-alkaloids might be arranged in a scale, with mescaline at the morphine-like extreme and lophophorine at the other: (morphine-like) mescaline, peyotline, anhaline, anhalamine, anhalonidine, anhalonine, lophophorine (strychnine-like). Peyotline, however, has a variable effect on different individuals, while anhalonine has been accounted of the morphine-like group by Rouhier.[1] The color-visions so conspicuous in peyote-intoxication are chiefly produced by mescaline.[2] Lophophorine is the most toxic.[3] Physiologically the effects of the individual alkaloids are:[4] _Mescaline_: slowing of pulse, slight headache, sensation of heaviness in the limbs lasting one to several hours; heavier doses, feeling of discomfort and fullness of stomach (even when injected intravenously) in addition to the above symptoms; still heavier doses, accentuation of symptoms and appearance of color-visions. _Peyotline_: in about an hour reduces the pulse approximately one-quarter the normal number of beats; two hours after ingestion, heaviness of eyelids, sensation of fatigue, aversion to all physical or mental effort; has no marked analgesic action but is a fairly good sedative and has a very appreciable hypnotic and anodyne action. _Anhaline_ [= hordenine]:[5] exercises a paralyzing effect on the central nervous system.