_Anhalamine_: this has not been adequately studied physiologically. Nor have _Anhalinine_ and _Anhalidine_. _Anhalonidine_: only slight sleepiness and dull sensation in head; pulse not affected. _Anhalonine_: produces no sensible effect, except perhaps a slight sleepiness. _Lophophorine_: the most toxic, has no narcotic action; a quarter-hour after ingestion an accentuated sickening feeling in the back of the head, with hotness and blushing of face, slight pulse diminution; symptoms disappear after 40 minutes. “In short,” says Rouhier,[6] “save for anhalonidine which, in strong doses, provokes in the frog paralysis of the motor nerve-ends (which is not observed otherwise in mammals), the alkaloids of peyote act on the central nervous system.... [Mescaline] acts on the brain, which it paralyzes. [Lophophorine] is antagonistic in action to this, augmenting the irritability of the spinal cord and its elongations.... Peyotline, anhalonine and anhalonidine hold a middle place between the two preceding. They produce in the frog a soporific effect (due to the paralysis of the brain or central nervous system), followed by an effect of tetanus. Anhalonidine and anhalonine have identical physiological effects. The paralyzing effect of the former is of long duration. That of the second is much reduced and is lacking in warm-blooded animals.” ACTION OF PAN-PEYOTL The native use of peyote, however, involves of course the whole series of alkaloids, and we must discuss the physiological effect of pan-peyotl preparations. Since antagonistic alkaloids are at work, it is not surprising to find several stages of physiological action with the whole plant. Dixon writes:[7] The action may be divided into a preliminary stage and a stage of intoxication. In the former there is excitement, a feeling of exhilaration, and diminished kinaesthetic sensations, performances involving effort being hardly noticed; the face is flushed, and the pupils dilated; there is a tendency to talkativeness, which may become wandering later, when the patient begins to feel “lightheaded.”