“What magnificent dwellings, what notable palaces were then depopulated to the last person! What families extinct! What riches and vast possessions left, and no known heir to inherit! What numbers of both sexes in the prime and vigor of youth, whom in the morning either Galen, Hippocrates, or Æsculapius himself but would have declared in perfect health, after dining with their friends here have supped with their departed friends in the other world!” From Marseilles the plague spread through Provence with disastrous results. In some monasteries not even a single survivor was left. In one of these Petrarch’s brother buried thirty-four of his companions. At Avignon, the seat of the Pope, 1,800 deaths occurred in three days. In Paris more than fifty thousand died of the plague. In England the black death appeared in August, 1348, and continued till the autumn of 1349, when it disappeared. London, which at that time probably had a population of 45,000, had a mortality of about 20,000. No exact statement can be made of the relative mortality in England, although many undoubtedly extravagant guesses are recorded by contemporaneous writers. It is estimated that the population of Europe previous to the outbreak of the black death was about one hundred and five millions. One quarter of the population, or about twenty-five millions, are said to have died of the plague. This may be but a mere estimate, it may be grossly inaccurate, but it nevertheless indicates the deadly character of the pestilence. According to a report made to Pope Clement VI, the total mortality for the known world was placed at forty-three millions. One-half the population of Italy succumbed. The Order of Minorites in Italy lost 300,000 members. The Order of Capuchins in Germany lost 126,000 members, while the total of deaths in Germany was placed at 1,200,000. The invasion of Europe by the black death was sudden and rapid. The seeds of the disease, once planted on European soil, persisted, as might be expected, for no little time. Although the great epidemic was said to have lasted till 1360, it must not be inferred that it then ceased altogether. Diverse localities retained the infection, and, as a result, new outbreaks, though to a less extent, continued to outcrop during the following years. From that time on every decade or two witnessed more or less pronounced outbreaks of the disease in France, England and Italy. The chroniclers of those local outbreaks during the latter half of the fourteenth and during the entire fifteenth century did not always make it clear that the pestilence described was the real plague. It was but natural to include typhus and other diseases under the dreaded term of pest. Nevertheless, the frequency of these outbreaks indicates the persistence and the wide dissemination of the plague during those years.