During the sixteenth century the plague apparently began to show a decrease in its frequency, although during this period, as before, other epidemic diseases were mistaken for it. Germany, Holland, certain cities in France, and especially in Italy were scourged by the plague during this century. The noteworthy outbreak in Italy in 1575-77 was due to fresh importation from the Orient. The disease spread throughout Italy, and the devastation it caused was not inferior to that of the great plague two centuries before. For example, in 1576 in Venice 70,000 died of the disease. During the seventeenth century the plague asserted itself with great severity. Following a famine, it prevailed in Russia in 1601-1603, and some idea of its destructiveness may be gained when it is stated that in Moscow alone 127,000 lives were taken. During the following decade even greater epidemics prevailed in Western Europe. France and England were invaded, and in Switzerland it even penetrated to the highest Alps. Basel in 1609-1611 had 4,000 deaths, while London in 1603 yielded 33,000. The terrible epidemic which ravaged Northern Italy in 1629-1631 deserves more than a passing notice. During those years more than a million died of the disease. Scarcely a town in Northern Italy escaped. The city which, perhaps, suffered the most was Milan, where, in 1630, the deaths from all diseases are said to have amounted to 186,000. The Milan outbreak has been graphically described by Manzoni, in his celebrated ‘I Promessi Sposi.’ Unrecognized, the disease entered Milan in October, 1629. The mild cases which were met with during the winter months lulled the fears of the people and encouraged the mass of physicians to deny the existence of the plague. But in April the disease began to assert itself in terrible earnest. The frenzied populace, blind to the contagiousness of the disease, were possessed with the strange hallucination that obtained during former plague epidemics in other Italian cities, that the pest spread because of poison scattered about by evil-minded persons. Suspicious strangers were, as a result, stoned in the streets, imprisoned and even put to death by legal process because of such fanatical beliefs. To offset the growing pestilence, the people demanded of the Archbishop that a solemn religious procession be held, and that the holy relics of Saint Charles be exposed. At first this was refused, but eventually it was granted. The procession bearing the saintly body was solemnly held on the 11th of June. The fanatical security which these devotions engendered was rudely shattered when, a few days later, the disease burst forth with renewed activity among all classes in all parts of the city. Nevertheless, as Manzoni observes, the faith was such that none recognized that the procession itself was directly the cause of the new outburst of the disease by facilitating the spread of the contagion.