In October 1861 Dr. W. C. Mackintosh published a Paper in the _Journal of Mental Science_ on “The Subcutaneous Injection of Morphia in Insanity,” which first drew my attention to this method of treatment. In the Reports of the Somerset Asylum, Dr. Boyd has also recorded his opinion of the value of this treatment in cases of maniacal excitement with sleeplessness, and in that form of destructive mania accompanied with dirty habits.[8] The detail of the hypodermic method of treatment is carefully stated in Dr. Anstie’s Paper, and to this I must refer those who desire farther information regarding it. I use a solution of 6 gr. of the acetate of morphia to the drachm; Dr. Anstie’s strength is 5 gr. I always commence with ♏︎v of the solution (½ gr.), and in only one case out of many hundred hypodermic injections of morphia has any injurious effects followed the remedy thus used. CASE I. _Recent Mania._—J. H. W., No. 1,563, female, aged 20, single; domestic servant. Form of disease, acute asthenic mania. _History._—Never had any previous attack. No history of insanity in her family. Has been engaged for some years as a domestic servant. No reason can be given for her illness. It is stated that for the last three or four months she has been strange, and at times depressed, and that about three weeks ago she suddenly became maniacal, and has remained in a state of violent excitement ever since. _Progress._—On admission at Hayward’s Heath, on the 22d of March last, she was in a state of the most intense maniacal excitement, and very incoherent. Physically, she was suffering from marked typhoidal symptoms, her pulse was feeble and very rapid, her skin dry and harsh, her lips and teeth covered with sordes, her tongue coated with a thick creamy fur. She refused all food, and had had no sleep for several nights. Although she could not be prevailed on to take any solid food, she was coaxed at times during the first two days after her admission to take ½ gr. of morphia in a little brandy, but she was almost invariably sick after it; moreover, the excitement continued, and she could obtain no sleep. On the third day the hypodermic injection of ½ gr. of morphia was commenced, and continued every four hours except during the middle of the night. On the fifth day she was calm, although incoherent, and had slept during the whole of the previous night, took her food well, and had lost nearly all the typhoidal symptoms. Moreover, the irritability of the stomach was completely allayed. She has since then recovered without a bad symptom, and she is now convalescent. This case showed in a very marked manner the advantage of the hypodermic injection of morphia over its administration by the mouth in cases, which so frequently occur, of acute mania with marked asthenia and irritability of the stomach, causing refusal of food.