In the first place she was treated with stimulants, sedatives, and a nourishing diet, but she remained from May 14th, the day of admission, until May 20th, without any improvement, and was becoming so reduced, from want of sleep and constant worry, that her life was despaired of. On the 20th May, 1868 (to quote from the case-book), “she passed a very restless night, and is much exhausted this morning: injected acetate of morphia gr. j, and she soon fell asleep; took her food well on awaking.” On the 23d, “injected gr. j of morphia twice daily since the last entry, and with decided benefit, and she is much less excited. Sleeps well, and the suicidal tendency seems to have passed away.” On July 15th the entry is as follows:—“Has improved uninterruptedly ever since the last entry, and is now tolerably sane.” She was discharged recovered on 7th December, 1868, and has continued sane to this date, although in such a case another relapse is most probable. ON THE THERAPEUTICAL VALUE OF THE INHALATION OF OXYGEN GAS. BY EDWARD MACKEY, M.B. LOND. ETC. _Joint Professor of Materia Medica and Therapeutics in Queen’s College, Birmingham._ Our ordinary medicinal agents are substances from the animal, the vegetable, and the mineral kingdoms: the one here to be treated of is of that class of remedies which includes the great elements or forces of nature: such are water, in all the varied forms of bath; electricity, in its different developments; air, in all its modifications of pressure or composition. It is unfortunate that the application of these mighty remedies seems liable to degenerate into charlatanism: partly perhaps because they have the power—_wrongfully_ claimed for quack medicines—of doing good in many apparently different forms of disease; partly because their use must at present be limited to the few, and does not admit of ready introduction into the practice of the many. Nevertheless, the truthful study of these agents offers scope for the highest science, and promises therapeutical results of the highest value. The following cases are offered as data for judging of the value of one of them. I do not propose to treat here of the chemistry of oxygen,[9] nor of its physiological effects, nor even of the objections which have been urged against its use—but simply to state facts which have come under my own observation. CASE I. _Emphysema pulmonum (hereditary)._—A lady of 55 had been for many years the subject of constant dyspnœa, increased on all movement, and often amounting to a sense of suffocation. A physical examination revealed sibilant râles with prolonged expiration heard all over the chest, which was of large capacity and more than normally resonant on percussion; the heart’s action was weak and the circulation embarrassed, as evidenced by œdema of the face and extremities.