CASE IX.—A lady of 21, after a period of great mental anxiety and of close application to business, began to feel extreme depression, drowsiness, anorexia, headache, nausea, and interscapular pain; the pulse was slow, the face pale; there were palpitation and dyspnœa without signs of organic disease. The symptoms had lasted about two months, when I first saw her in July 1868. She took alkalies, aperients, and appropriate medicines, and on the 12th took inhalation, 7 pints in 60. Here again the same remarkable effect was produced, in relieving headache before the end of the quantity. She continued to inhale a little larger dose every third day for a fortnight, without taking any medicine for the latter part of the time. She has remained fairly well ever since, and voluntarily expressed the great benefit which she derived from the gas, especially as to relieving a sense of constriction across the chest and dyspnœa. Both these cases were tolerably acute, and occurred in persons of naturally “sanguine” temperament, but it is necessary to record that another case which I have treated more recently,—a young lady of “bilious” temperament, who suffered from hepatic congestion in a more chronic form,—found no special effect whatever from inhalations taken on alternate days, for a fortnight. CASE X. was one of albuminuria in a lady of 57. The disease had commenced four years before, and her health had been markedly impaired for the last twelve months (dating from an attack of vertigo, and loss of consciousness). Last winter she had had bronchitis. She was a lady highly connected, and had been under the care of several eminent London physicians, who had concurred in advising her to go into the country for a time, and I was sent for to see her in November last, when she had already been at a country-house in this neighbourhood for some months. She was feeble, with pallid face and injected cheeks; extremities œdematous; dyspnœa to a great extent on the slightest exertion; tendency to fainting and giddiness; urine deposited urates, and gave a cloud of albumen with the usual tests. Almost the only remedy which had not been given to her was this gas. I requested her to write and ask her physician if he concurred in its use; he wrote back to say “by all means,” and on November 18 she began with 14 pints in 60 of air. The pulse was 78 at commencing, and did not vary. She took it six times at intervals of three days. I had anticipated good from it, but there was really no marked effect. She thought, in fact, that her headache was rather worse afterwards, but I think that was better accounted for by the carriage drive to my house and the extra excitement.