Treatment was omitted for a time, and in the interval she got an attack of subacute bronchitis; on recovery she hired an apparatus of her own, and began, on December 12, 16 pints to 60. I consider that she had a week’s fair trial, but at the end of that time, what with leakage in the machine and non-arrival of gas, the lady’s patience failed, and the treatment was not persevered with. I mention these matters as an instance of one of the difficulties that an unusual mode of treatment must necessarily contend with. However, the result of this treatment, such as it was, gave no encouragement to persevere. CASE XI. resembled the last in the fact of there being organic disease. She was a delicate and refined lady, of the age of 34, unmarried. With a history of some years of spinal debility, and of congestive headache, at this time (September 1868) there was general prostration, numbness, and tingling in various parts, a sense of suffocation and of constriction, and partial loss of power over limbs; but worse than all, the attacks of headache of frightful intensity, attended with throbbing, flushing, and confusion of thought, and generally located over the left eye, which then protruded very much. Of these and other symptoms, some were explicable on the hypothesis of congestion of the spinal cord, and parts of the cerebrum, while some suggested a grave suspicion of ramollissement; others, again, of a chronic thickening of the membranes. My opinion was necessarily doubtful, but with regard to remedies oxygen offered a prospect of relieving at least some of these symptoms; it is said to have done so in recorded cases. Moreover, the patient had had the best obtainable advice in her own town of Wolverhampton and in the city of Cork, remedies prescribed by her physician had not benefited her, and for some months she had been under homoeopathic treatment at home and at Malvern. I recommended her to hire an apparatus for her own use; and on October 4 she began with 12 pints to 50 of air, the inhalation to be extended over the period of one hour. The necessary exertion tired her, and she felt no appreciable relief. I did not like to wait longer without attempting to relieve by some of our usual remedies, and I prescribed gr. viij pot. brom. with ♏︎viij. liq. ergotæ, as having a special influence in equalizing the spinal circulation. _Oct. 12._—Head bad, but not so bad as usual. On 15th, menstruation came on, and aggravated symptoms somewhat. I directed inhalations to be increased in strength every day, until I reached equal proportions of air and oxygen—as much as 30 pints of each.