Upon the second inoculation, however, the incised parts are commonly inflamed for a day or two, just in the same manner as I have, in numerous instances, found them to be, as well in those who, though certain of having had the small-pox in the natural way, have submitted to be inoculated merely for the experiment sake, that the result might be observed; as in others, who, being doubtful whether they have had it or not, have been inoculated, in order to be satisfied. But in all such cases the parts soon became well; nor did any of those appearances which have been described as the constant attendants on inoculation, as pain in the head, giddiness, marks of infection in the arm, &c. ensue; nor can they ever be produced upon a person who has had the small-pox before, either in the natural way or by inoculation; and therefore it cannot with reason be suggested, that the patients, whom I suppose to get through the disease in the very slight manner above described, may possibly have had the small-pox unobserved in some former part of their lives. Another irregularity deserving notice here, is, that sometimes, upon the abatement of the fever and other symptoms, after the appearance of several pustules, and when the eruptive stage of the disease seems completed, it nevertheless happens that fresh eruptions come out, and continue doing so daily, for 4, 5, or even 6 days successively; preceded sometimes by a slight pain in the head, though more frequently they appear without any new disturbance. These are generally few in number, short-liv’d, and seldom come to maturity. But I have seen four cases, in each of which, after a cessation of complaints, and an appearance of few pustules, the eruptive stage of the disease was thought to be over, yet in two or three days a fresh fit of fever has attacked the patients, and after a short illness a quantity of new pustules has broken out, far exceeding the first number, and these remained, and maturated completely. Instances of this kind may be found among the cases annexed[3]. [3] Vide Cases XV. XVI. XVII. XVIII.