In this case the inoculated part shews early certain marks of infection, sometimes on the very next day, or the day after, when the incision will often appear considerably inflamed and elevated. The patient about this time frequently makes some of the following complaints, viz. chillness, itchings, and small pricking pains in the part, and sometimes on the shoulder, giddiness, drowsiness, and a slight head-ach, sometimes attended with a feverish heat, but often without any: the account they themselves give of their feelings, is, in some, as if they had drank too much, and in others, as if they had caught a cold. These complaints seldom last twenty-four hours, often not so long, and with frequent remissions, and never, that I remember, rise to a degree that requires confinement. The inflammation on the arm at the time of the complaints, advances apace, and feels hard to the touch; but upon their wearing off, the inflamed appearances gradually lessen, and the part dries to a common small scab; the skin that was before red, turns livid, and the party is quite well, and nothing more heard of the distemper[2]. In some instances these symptoms attack much later; even on the seventh or eighth day, when an eruption might be expected in consequence of them, yet none appears; but the arm gets well very soon, and the disease is at an end. [2] See Case I.-XII. In this irregular sort of the disorder there have, however, been some examples where a few eruptions have appeared, and probably in consequence of the inoculation; yet the pustules have not looked like the true pocks, nor maturated like them, nor lasted longer than three days; about which time they, for the most part, have dried away. As I find it difficult to describe the variety and irregularity of symptoms that occur in this short way of having the distemper, I will give some cases, by way of illustrating the matter more to the reader’s satisfaction. When subjects of this sort first occurred in my practice, I was in doubt whether they were quite secure from any future attacks of the distemper; and in order to try whether they were so or not, I inoculated them a second time, and caused them to associate with persons in every stage of the disease, and to try all other means of catching the infection; and this method has been practised with the generality of such patients ever since, yet without a single instance of its producing any disorder: so that I now make no scruple of pronouncing them perfectly safe; and experience has enabled me, for the most part, to foretell, in two or three days after the operation, when the disease will pass in this slight manner.