I did not see him till the 11th, when he came to the house: he was then perfectly well, but said he had been a little giddy for the last day or two, and that his head had ached very much the preceding day for about an hour, insomuch that he thought he must have come over; that his arm had itched very much, and the purge had worked very briskly. Upon examining the arms, both incisions appeared to be considerably inflamed, and looked just as is usual on the approach of the eruptive fever, which I had not the least doubt would soon happen. On the 12th he complained of some pain in the right shoulder, and under the arm, which he said was stiff, and felt as if it was swelled. However, he continued perfectly well and free from all complaints to the 15th; the arms appearing as is usual when the distemper is attended with very few pustules; that is to say, not quite free from inflammation, but with a slight one. The case being not so clear as could be wished, in order to be thoroughly satisfied, I inoculated him again, taking particular care to infect the part well. On the 16th in the morning he took a dose of Inf. Sen. and Manna. He continued quite well, and no itching or signs of infection appeared from the last inoculation. CASE V. May 3d.] A man of 44 was inoculated. I saw him every day, and it was easy to perceive that the infection had taken place very early. On the 7th it appeared so forward, that I ventured to prognosticate he would have a very early and mild disorder, and no eruption. On the 8th he complained of a pain in his head and back, and that he felt a general uneasiness, attended with a loss of appetite, which at other times was very good. He continued complaining in this manner that whole day, but on the next found himself pretty well, and continued so without any other illness. The inflamed appearance on the incision abated from this time. His health returned, and he still remains perfectly well. CASE VI. A middle-aged man was inoculated at the same time; whose case in every circumstance so nearly resembled the former, as to render it needless to enumerate the particulars. Both were inoculated a second time without any eruption or signs of infection happening in consequence of it. CASE VII. Dec. 5th.] A healthy man of 38 was inoculated. On the 7th he called on me, when his arm itched very much, and shewed certain marks of the infection having succeeded. The inflammatory appearance was then considerably abated, and the incisions seemed disposed to heal. He felt no uneasiness on the part, nor had he any illness.