On the 12th and 13th he complained of pains in his head and limbs, as also of stiffness under his arms, which I esteem one of the most certain proofs of the infection having taken place. There was no alteration in the pulse, nor any other sign of a fever; a few pimples about the neck and arms followed these complaints, yet not such as I should have esteemed variolous on any other occasion: for some soon disappeared; and others, which remained long enough to have a little matter formed in them, proceeded to this state with great irregularity. He was inoculated again, but without the least effect. CASE VIII. A man between 50 and 60 was inoculated about four in the afternoon: on the morning of the third day after the inoculation I first saw his arms, when they shewed uncommon signs of infection, being already much inflamed; and upon inquiry, I received from him the following account: that on the same evening he was inoculated, he felt an uneasiness and numbness at and near the place of insertion; and that the day following, these complaints increased, and spread up to the shoulder of one arm, which was very stiff and numbed; that the incision had itched several times, and his arms felt as if he had been bruised by a blow with a very large stick. And on the preceding evening, which was the second from the inoculation, his head had been giddy and in pain, accompanied with some chilly fits; but all these sensations went off without any other illness. He had rested well, and never thought himself in better health. From this time I saw him at different times every day, and he continued in perfect health; only sometimes, especially towards evening, he said he felt as if he had drank too much. The arms were much inflamed; but on the 6th and 7th day they altered their colour to a darker hue, and the inflammation and hardness were evidently abating. He now desired to go a journey of about 20 miles on business; and this I consented to, from an absolute confidence that he was secure from any alarming attack; having first enjoined him not to go into company where he might risque spreading the infection; for his breath at this time had that peculiar offensive smell which accompanies the disease. He returned the following day, being the 8th, in the afternoon, making no complaint, but of hunger; yet said his head had ached the preceding night after his journey. His arms were now rather more inflamed, which I attributed to the friction they might have in the chaise; but from this time all complaints of every kind ceased. His arms soon became quite well; he took his first purge on the following day, a second on the 11th, and returned home on the 13th from the inoculation, without having a single eruption of any kind.