It is remarkable in this gentleman’s case, that being so well he did not chuse to live with those who had the distemper, but continued in a lodging with his wife, who accompanied him by way of nurse, in full confidence of having had the small-pox many years since. However, after they got home, she fell ill, and had the distemper in a very clear but favourable manner, and doubtless caught it off her husband. CASE IX. A young gentleman aged nineteen was inoculated June 2d, 1765. On the 3d he rode out with a friend in an open chaise, and it being stormy weather, returned home wet. I called on him next morning, and found him in bed, complaining that he had rested ill, felt shooting pains in his head, his throat a little sore, thought himself feverish, and that he had taken cold the preceding day. All this seemed very probable; his pulse was too quick, though the heat not considerable, and he was in a moderate sweat. He rose about ten, and kept within doors the whole day, complaining of weariness, slight pain in the head and about the shoulders; also that the incised parts felt uneasy, and itched. On the 5th he thought his cold considerably better, and ventured abroad. His arm appeared certainly infected, and very forward; insomuch that I suspected he would have no more illness in consequence of the inoculation. On the 7th the inflammation on the arm was considerably abated, and the incision seemed disposed to heal. Apprehending from these circumstances that nothing more was to be expected from the operation, he was inoculated again in the evening, from a person who had the distemper pretty full, though of a distinct kind, in the natural way. No marks, however, of infection ensued from this last operation; and he continued visiting with me many patients in all stages of the disease: so that it is probable he was then in more danger of infection than he will ever be again. CASE X. Dec. 19.] A healthy florid young man was inoculated in both arms; and soon after on the same day he felt a disagreeable numbness and stiffness, beginning at the incision in one arm, and extending as high up as the shoulder. That night at going to bed he took five grains of calomel in a pill. On the 20th the same kind of sensation in the arm remained, extending also to that side of the head, which was in some pain. These complaints continued this day and the next. I ordered him to take the same mercurial pill at going to bed. 22d. Another indifferent night, with the same complaints, and a stiffness in both shoulders. The pulse appeared to be rather quickened, but without any such increase of warmth as was sufficient to be called fever. The incisions were unusually forward. 23d. In the morning I was told he was better, and had taken a ride to visit his mother at about ten miles distance; also that he had several pimples, which were believed to be the distemper.