As I have no personal experience of spermine, I shall quote from Professor Poehl[112] some indications of its efficacy. Several physicians (Drs. Maximovitch, Bukojemsky, Krieger and Postoeff) have given injections of spermine to enfeebled old men who had lost appetite and sleep, and have noted improvement lasting for months. From the instances given, I have selected that of an old lady of ninety-five years, afflicted with severe sclerosis of the arteries, with no appetite, a bad digestion and constipation. This patient had complained for several years of sacral pains, and moreover was nearly quite deaf and suffered from periodic attacks of malarial fever. The injections of spermine, given for a period of fifteen months, restored the old lady to such an extent that she recovered her power of hearing and felt the sacral pains only slightly and after a long walk. Her general condition was highly satisfactory. Spermine, as it has been used medically, is prepared not only from the testes of animals but from the prostate gland, ovary, pancreas, thyroid gland and spleen. The substance is not specially associated with spermatozoa but has a wide distribution in the mammalian body. In the medical treatment of the evils of old age, testicular emulsions or spermine have not been so favoured as general hygienic measures. Dr. Weber,[113] a London medical man, has recently summarised more general measures, and his evidence is the more important as he has been able to test the efficacy of his precepts in his own case. Dr. Weber is 83 years old, and in his practice has cared for many other old men. The following are the precepts which Dr. Weber formulated: All the organs must be preserved in a condition of vigour. It is necessary to recognise and subdue any morbid tendencies whether these be hereditary or have been acquired during life. It is necessary to be moderate in food and drink, and in all other physical pleasures. The air should be pure in the dwelling and in the vicinity. It is necessary to take exercise daily, whatever be the weather. In many cases the respiratory movements must be specially exercised, and exercise on level ground and up-hill should be taken. The persons should go to bed early and rise early, and not sleep for more than six or seven hours. A bath should be taken daily and the skin should be well rubbed, the water used being hot or cold, according to taste. Sometimes it is advantageous to use hot and cold water. Regular work and mental occupation are indispensable. It is useful to stimulate the enjoyment of life so that the mind may be tranquil and full of hope. On the other hand, the passions must be controlled and the nervous sensations of grief avoided. Finally, there must be a resolute intention to preserve the health, to avoid alcohol and other stimulants as well as narcotics and soothing drugs.