Beveridge[78] suggests the use of secretin in (_a_) pyloric stenosis, (_b_) pancreatic insufficiency, (_c_) hepatic stimulation and cirrhosis of the liver (_d_) to stimulate peristalsis in colonic stasis, (_e_) in gastro-enterostomy and short-circuiting of the intestines. He claims to have used it in over a hundred cases with “brilliant results,” and cites four typical histories. The G. W. Carnrick Company, which manufactures “Secretogen,” an alleged secretin preparation, cites a number of authorities[79] as also recommending secretin for digestive disorders. Harrower, who is or was connected with the Carnrick Company, in clinical journals[80] has ardently advocated the use of secretin for a large number of maladies. [78] Beveridge: Am. Med. =20=:255, 1914. [79] Lockwood, G. R.: Diseases of Stomach, 1913, Chapter on Achylia. Bassler, Anthony: Am. Jour. Gastro-Enter., 1914; Kemp, R. C.: Diseases of Stomach, Intestine and Pancreas, 1912. Reed, Boardman: Am. Jour. Gastro-Enter., October, 1912. Ewald (Therapie der Gegenwart, 1915, p. 5) reports favorable results with Secretogen in one of thirteen cases. [80] Harrower: Pediatrics =25=:430, 1913; New York M. J. =118=:315, 1913; Arch. f. Verdauungskr. =20=:577, 1914. PHYSIOLOGIC CONSIDERATIONS Throughout its clinical use, secretin has been given by mouth; _but its direct introduction into the intestine of a dog under anesthesia in even enormous quantities is without effect_. This fact, first observed by Bayliss and Starling,[32] was confirmed by Fleig,[81] and Matuso,[36] and our personal experiments have convinced us of its truth. Matuso found that ordinary secretin and that obtained from intestinal lumen gave equally negative results. Large quantities of active secretin, moreover, acidified to 0.2 per cent. hydrochloric acid, and left in the ileum for fifteen minutes, were still negative. Wertheimer and Duvillier,[82] in a previous paper on this subject, had likewise found that acid solutions of secretin (which might be considered more normal for the intestine than when neutral), when introduced into the ileum gave negative or inconstant results. They conclude that it is more likely that the pancreas does not respond to such minimal stimuli, than that the secretin is not absorbed. [81] Flieg: Arch. gén. de méd. =191=:1482, 1903. [82] Wertheimer and Duvillier: Compt. rend. Soc. de biol. =68=:535, 1910.