The sample kept intact in its original container for six months became gradually cloudy, a large mass of amorphous precipitate settled to the bottom and the odor showed bacterial decomposition. It is reprehensible, to say the least, to state concerning such a mixture: “Of course, if desired, it may be injected intravenously.” The fact that Beveridge’s secretin may be rendered clear by filtering through carbon is not sufficient evidence that it is “pure secretin,” free from bacteria and other injurious substances. II. _Beveridge Secretin Mixture Is Rapidly Rendered Inactive by Human Gastric Juice._--We prepared active secretin solutions by the Beveridge method, using 0.2 per cent. serum as the protein “stabilizer” (?). The addition of the serum does not appear to affect the activity of the fresh secretin preparation. If Beveridge’s secretin is able to act on the pancreas when given by mouth, it is obvious that it must run the gamut of gastric digestion, except in cases of complete achlorhydria. It has been repeatedly demonstrated that all other secretin preparations are rapidly destroyed by pepsin-hydrochloric acid digestion. Is Beveridge’s secretin an exception? What is there in a little serum, native albumin, or peptones to protect secretin against gastric digestion? The pure human gastric juice used in these tests was secured from the fistula case (Mr. F. V.) that has been under observation in our laboratory for years.[123] [123] Carlson: The Control of Hunger in Health and Disease, Chicago, 1916. BEVERIDGE’S SECRETIN AND BAYLISS-STARLING SECRETIN PREPARED Sept. 29, 1916 ================================================================ Response of Pancreas (No. of Drops of Secretin) Date of Test Quantity of ┌───────────┴───────────┐ Secretin Bayliss-Starling Beveridge Injected, C.c. Secretin Secretin Sept. 29. 10 75 78 Oct. 2. 10 61 61 Oct. 6. 10 28 17 Oct. 13. 10 25 31 Oct. 27. 10 5 6 Nov. 3. 10 7 6 Nov. 17. 10 4 5 Nov. 30. 10 3 4 Dec. 4. 10 2 2 Dec. 20. 10 0 0 ----------------------------------------------------------------