Lady Mary Wortley Montagu returned to England in 1718, but not until 1721 did she fulfil her intention of making war on the doctors, and incurring their resentment for the good of mankind. In the spring of 1721 she commenced action in earnest by the inoculation of her daughter--the infant that it was considered unsafe to “engraft” when at Pera in 1718. In Maitland’s words-- The noble Lady sent for me last April, and when I came, she told me she was now resolved to have her daughter inoculated, and desired me forthwith to find out matter for the purpose. I pleaded for a delay of a week or two, the weather being then cold and wet. I also prayed, that any two physicians whom she thought fit, might be called, not only to consult the health and safety of the child, but likewise to be eye witnesses of the practice, and contribute to the credit and reputation of it. This was at first denied me, it might be out of a design to keep it secret, or lest it should come to nothing. In the meantime having found proper matter, I engrafted the child in both arms, after the usual manner. She continued easy and well till the tenth night, when she was observed to be a little hot and feverish. An ancient apothecary in the neighbourhood being then called, prudently advised not to give the child medicine, assuring the parents there was no danger, and that the heat would quickly abate, which accordingly it did, and the smallpox began next morning to appear. Three learned physicians of the college were admitted, one after another, to visit the young lady; they are all gentlemen of honour, and will on all occasions declare, as they have done hitherto, that they saw Miss Wortley playing about the room, cheerful and well, with the smallpox raised upon her; and that in a few days after she perfectly recovered of them. Several ladies, and other persons of distinction, also visited this young patient, and can attest the truth of this fact. One of the learned physicians who had visited Miss Wortley, having some years since fully informed himself of this method of practice, and being thoroughly satisfied of the safety and reasonableness of it, at length resolved to try it in his own family; he had formerly lost some children in a very malignant kind of the smallpox, and therefore advised me to lose no time to engraft the only son he had left. The boy (who was not quite six years of age) being of a pretty warm and sanguine complexion, the Doctor ordered about five ounces of blood to be taken from him; and then, in ten days after, having found matter which he liked, I inoculated him in both arms. This was performed the 11th of May, 1721.