_Rabbit 327. White, female. Weight, 820 grams. Diet, oats, March 8 to 16._ March 16: 11.45 a. m., 12 cc 2 per cent caffein (292 mg per kilo) injected subcutaneously in the back; 2 p. m., found dead, but was still warm. _Autopsy_: Hemorrhagic area at point of injection into spinal muscles; subcutaneous abdominal region exhibited a large area of cheesy purulent material; liver and spleen were engorged; bladder filled; intestines normal. _Rabbit 340. White and brown male. Weight, 1,465 grams. Diet, oats._ March 30: 3.20 p. m., 20 cc of 2 per cent caffein (273 mg per kilo) injected subcutaneously in back. March 31: 9 a. m., found dead. _Rabbit 341. White and brown. Weight, 1,450 grams. Diet, oats._ March 30: 3.20 p. m., 20 cc 2 per cent caffein (270 mg per kilo) injected subcutaneously in back; 4.40 p. m., found in dying condition, had convulsions; 4.45 p. m., dead. _Rabbit 326. White, male. Weight, 1,645 grams. Diet, oats, March 8 to 16._ March 16, 1910: 12 noon, 20 cc 2 per cent caffein (243 mg per kilo) injected subcutaneously in the back; 2 p. m., tremors marked, hypersensitive, started to run when put on floor; rabbit was not handled any more than was required for his removal from and return to cage. March 17: 9.30 a. m., tremors still present and marked, otherwise general condition good; no other symptoms. March 18: 9.30 a. m., no appetite, tremors still present, general condition poor; died about 2 p. m. _Rabbit 235. Belgian hare, male. Weight, 1,870 grams. Diet, carrots, November 2 to 9._ November 10: 11.05 a. m., 25 cc 2 per cent caffein (267 mg per kilo) injected subcutaneously; reflexes increased and tremors, but no tetanus observed; found dead next morning. _Rabbit 316. Belgian hare, female. Weight, 860 grams. Diet, oats, March 8 to 16._ March 16, 1910: 11.40 a. m., 12 cc 2 per cent caffein (267 mg per kilo) injected subcutaneously in the back; 2.15 p. m., reflexes somewhat increased, but not markedly so; walked when put on floor; gait clumsy and slow; tremors of head observed; 2.35 p. m., rabbit lying in his cage, posterior extremities extended and rigid, anterior extremities flexed, head retracted; is still breathing; occasional spasms observed. Rabbit died at 3 p. m. _Autopsy_: No lesion at point of injection in dorsal spinal muscles; liver and spleen engorged; intestines injected; other organs apparently normal. _Rabbit 395. Belgian hare, male. Weight, 1,410 grams._ August 18: 1 p. m., 20 cc 2 per cent caffein (283 mg per kilo) injected subcutaneously in the back; 4 p. m., reflexes markedly increased; 5 p. m., reflexes about the same, but no tetanus. August 19, 9.15 a. m.: Reflexes increased markedly. August 21, weight, 1,215 grams. Given 275 mg per kilo of caffein; no symptoms observed.