The Toxicity of Caffein: An experimental study on different species of animalsSalant, William
Science
The Toxicity of Caffein: An experimental study on different species of animals
Salant, William
Caffeine -- Physiological effect
August 23, found dead. _Autopsy_: Liver greatly engorged; stomach
fairly well distended and mucous membrane in a slightly inflammatory
condition; contents of small intestine liquid in nature, but walls of
same appeared normal; other organs normal in appearance.
_Rabbit 396. Belgian hare, female. Weight, 1,475 grams. Diet, oats._
August 18: 1 p. m., 20 cc 2 per cent caffein (272 mg per kilo) injected
subcutaneously in the back; 4 p. m., reflexes increased markedly;
5 p. m., reflexes increased markedly but no tetanus.
August 19: 10.30 a. m., reflexes still increased very markedly; rabbit
jumps when touched.
August 21: Weight, 1,245 grams. Injected subcutaneously 275 mg of
caffein per kilo; reflexes increased, posterior extremities stiff over
hour later.
August 22: 9 a. m., found dead. _Autopsy_: Thoracic organs normal in
appearance; stomach distended and mucous membrane affected with a
catarrhal inflammation; contents of stomach were covered with a shiny
mucus; contents of small intestine liquid in nature and bile stained;
liver showed a coccidial infestation; kidneys and spleen normal in
appearance.
_Rabbit 397. Belgian hare, male. Weight, 1,375 grams. Diet, oats._
August 19: 10.30 a. m., 20 cc 2 per cent caffein (290 mg per kilo)
injected subcutaneously in the back.
August 22: 9 a. m., found dead. _Autopsy_: Stomach distended with
ingesta; mucous membrane exhibited a catarrhal inflammation with
excessive secretions; major portion of intestines showed a condition
similar to that of stomach, contents consisting mainly of a shiny
mucus; liver enlarged; other organs apparently normal.
_Rabbit 398, Belgian hare, female. Weight, 1,570 grams. Diet, oats._
August 19: 10.30 a. m., 23 cc 2 per cent caffein (293 mg per kilo)
injected subcutaneously in the back; 4 p. m., found dead. _Autopsy_:
Thoracic organs seemingly normal; mucous membrane of stomach exhibited
a catarrhal inflammation generally; large intestines somewhat impacted
but walls appeared normal; other organs normal.
_Rabbit 399, Belgian hare, male. Weight, 1,725 grams. Diet, oats._
August 19: 10.30 a. m., 26 cc 2 per cent caffein (300 mg per kilo)
injected subcutaneously in the back; found dead at 4.30 p. m.
_Autopsy_: Lungs slightly congested; liver engorged and friable; gall
cyst well filled; stomach exhibited catarrhal gastritis; injection of
mesenteries and intestines; kidney showed marked cortical congestion.
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