June 10: Reflexes less than on previous day and less marked than in No. 136, a few cubic centimeters dirty brown urine collected but could not be tested for reduction. June 13: Condition good, appetite good. June 16: 9 a. m., found dead. _Guinea pig 134. White and brown male. Weight, 740 grams. Diet, hay and oats._ June 9: 2.55 p. m., 6 cc warm 2 per cent caffein solution given by mouth through stomach tube; 4.50 p. m., reflexes increased. June 10: 9.30 a. m., reflexes much less than day before, increase slight, a few cubic centimeters of urine passed since injection of caffein, looked brown and dirty, could not be tested for reducing substances. June 13: Guinea pig alive, appetite good, condition good. June 14: 9 a. m., found dead. _Guinea pig 128. White and black male. Weight, 1,075 grams. Diet, hay and oats._ June 7: 10 a. m., 11 cc 2 per cent caffein by mouth through stomach tube; 11.10 a. m., no symptoms, no urine passed; 1 p. m., increased reflexes, about 15 cc (estimated) urine passed; 4 p. m., reflexes increased, still more urine passed (about 20 cc); 4.50 p. m., tetanus, frequent attacks, then paralysis and death at 4.58 p. m. _Autopsy_: Lungs congested; blood vessels of heart injected; intestines slightly congested; fatty liver. _Guinea pig 126. White and gray male. Weight, 980 grams. Diet, oats and hay._ June 7: 9.40 a. m., 9.8 cc 2 per cent caffein given by mouth through stomach tube; 10 a. m., no symptoms; 11.10 a. m., no urine passed, reflexes increased; 1 p. m., more sensitive than before; 4 p. m., increase of reflexes more marked, no urine passed; 4.45 p. m., about 15 cc urine collected; 5 p. m., no change. June 8: 9 a. m., reflexes about the same as 5 p. m. previous day, no urine passed since 4.45 p. m. previous day, considerable reduction of Fehling's solution, much more than urine of guinea pig No. 127; 11.05 a. m., convulsions; 12 noon, still alive and stretched out on abdomen; died at 1 p. m. _Autopsy_: Lungs badly congested; heart and blood vessels injected; blood vessels of kidney and of small intestines injected; liver engorged with blood; a few necrotic spots in stomach. _Guinea pig 127. White, black, and brown male. Weight, 760 grams. Diet, oats and hay._ June 7: 9.50 a. m., 7.6 cc 2 per cent caffein by mouth through stomach tube; 10 a. m., no symptoms; 11.10 a. m., reflexes increased, no urine passed; 1 p. m., very sensitive; 4 p. m., sensitiveness increased, about 20 cc urine passed; 5 p. m., no change. June 8: 9 a. m., reflexes about the same as 5 p. m. previous day; 9.30 a. m., guinea pig passed 30 cc urine since he received caffein, urine showed a moderate amount of reduction; 12 noon, convulsions; died at 2.30 p. m. _Autopsy_: Lungs congested; blood vessels of heart and of intestines injected; numerous necrotic spots in stomach; other organs apparently normal.