----+--------+-------+-----------+------------------------------------ | |Caffein| | No.| Weight.| per | Results. | Remarks. | | kilo. | | ----+--------+-------+-----------+------------------------------------ |_Kilos._|_Gram._| | 47 | 13.60 | 0.144 |Survived |Vomiting observed. 55 | 12.75 | .200 | do. |Stiffness of muscles; no other | | | | symptoms. 56 | 7.95 | .200 |Found dead | | | | next day | 52 | 13.60 | .147 |Survived | 57 | 6.50 | .230 | do. |Vomited after 1 hour; convulsions | | | | after 1 hour and 45 minutes. 39 | 23.10 | .120 | do. |Increased frequency of respiration, | | | | thirst, loss of appetite, vomited | | | | rest of day when he drank water, | | | | salivation, restlessness, passed | | | | feces frequently. 48 | 11.50 | .174 | do. |Vomiting observed. 48 | 12.00 | .200 |Found dead |No vomiting observed. Second dose | | | next day | was given 8 days after first. 54 | 13.40 | .200 |Survived |Vomiting observed. 49 | 13.15 | .152 |Found dead | | | | next day | 38 | 14.50 | .120 | do. |Symptoms after 1½ hours: Dog had | | | | a temperature of 104° F. before | | | | caffein was given; vomited 3 hours | | | | after caffein was fed. 18 | 10.80 | .145 | do. | ----+--------+-------+-----------+------------------------------------ TABLE 13.--_Subcutaneous injection; dogs._ (_Series B._) ----+--------+-------+-----------+------------------------------------ | |Caffein| | No.| Weight.| per | Results. | Remarks. | | kilo. | | ----+--------+-------+-----------+------------------------------------ |_Kilos._|_Gram._| | 62 | 9.30 | 0.161 |Survived |Restlessness and vomiting one-half | | | | hour after injection. 61A| 14.00 | .160 |Found dead | | | | next day | 63 | 12.00 | .150 |Survived |Restlessness 1 hour after injection. 64 | 14.00 | .150 | do. |Restlessness and thirst 45 minutes | | | | after injection. 59 | 7.20 | .160 |Died 1 hour|Marked restlessness, but no | | | and 20 | convulsion. | | | minutes | | | | after | | | | injection.! 61 | 14.60 | .143 |Survived |Symptoms observed in 1½ hours. ----+--------+-------+-----------+------------------------------------ TABLE 14.--_Administration by mouth to puppies._ (_Series C._)