_Houlton._ I know that they are most powerful. If he perceives a symptom in patients of a great fever, or a probability of their having more pustules than they would chuse, he quickly prevents both by virtue of his medicines. _Couns. for the Cr._ Do you recollect any particular instance of this extraordinary virtue of his medicines? _Houlton._ I do. A child belonging to Mr. Barnard, of Waltham in Essex, was seized with the natural small pox. As soon as it was discovered, by the pustules making a plentiful appearance, the child was conveyed to one of Mr. Sutton’s houses. The next morning, the face and body being extremely full, Mr. Sutton marked with a pen a great number of pustules, and administered the medicine I allude to: some hours afterwards, hundreds of the pustules disappeared; and among them several of those marked leaving the little dot on the plain surface of the skin. The child did extremely well. _Couns. for the Cr._ Sir, you may retire. Dr. GEORGE BAKER sworn. _Couns. for the Cr._ Pray, Dr. Baker, inform the Court what you know concerning the Prisoner’s practice of inoculation. _Dr. Baker._ I can give the Court but little information from my own knowledge; but what I have to say, I received from a gentleman, whose accuracy in observing, as well as veracity in relating what he observed, may be relied on. All persons are obliged to go through a strict preparatory regimen for a fortnight before the operation. During this course, all fermented liquors and animal food, except milk, are forbid. Fruit is generally allowed, except on the days of purging. A powder is given three several times, and a dose of purging salt on the following morning. The composition of this powder is a secret. But that it contains mercury is evident, from its having salivated some patients. _Couns. for the Cr._ I beg, gentlemen of the jury, you will please to remember that the Doctor says, the composition of the powder is a secret. Now, Sir, please to proceed to his manner of communicating the disease. _Dr. Baker._ The operator opens a pustule on the arm of some patient in whom the matter is yet in a crude state; and then with his moist lancet just raises the cuticle on the arm of the person to be inoculated, applying neither plaister nor bandage. This was his method some time ago; but he now generally dips his lancet only in the moisture issuing from the place of incision, before the eruption, four days after the operation. _Couns. for the Cr._ And pray, Sir, what medicines does he give after the operation? _Dr. Baker._ On the night following, the patient takes a pill, which is repeated every other night till the fever comes on. _Couns. for the Cr._ Do you know the composition of this pill? _Dr. Baker._ No: it is a secret. _Couns. for the Cr._ Are the patients confined to their apartments at this period? _Dr. Baker._ No: moderate exercise in the open air is strongly recommended.