It may be added, however, that though the Indians were aware of the febrifugal qualities of this bark, they attached little importance to them, and this may be another reason for the lapse of time which occurred before the knowledge was imparted to the Spaniards. Referring to this circumstance La Condamine says, "Nul n'est saint dans son pays." This indifference to, and in many cases even prejudice against the use of the Peruvian bark, amongst the Indians, is very remarkable. Poeppig, writing in 1830, says that in the Peruvian province of Huanuco the people, who are much subject to tertian agues, have a strong repugnance to its use. The Indian thinks that the cold north alone permits the use of fever-bark; he considers it as very heating, and therefore an unfit remedy in complaints which he believes to arise from inflammation of the blood.[6] Humboldt also notices this repugnance to using the bark amongst the natives; and Mr. Spruce makes the same observation with respect to the people of Ecuador and New Granada.[7] He says that they refer all diseases to the influence of either heat or cold; and, confounding cause and effect, they suppose all fevers to proceed from heat. They justly believe bark to be very heating, and hence their prejudice against its use in fevers, which they treat with _frescos_ or cooling drinks. Even in Guayaquil the prejudice against quinine is so strong that, when a physician administers it, he is obliged to call it by another name. In about 1630 Don Juan Lopez de Canizares, the Spanish Corregidor of Loxa, being ill with an intermittent fever, an Indian of Malacotas is said to have revealed to him the healing virtues of quinquina bark, and to have instructed him in the proper way to administer it, and thus his cure was effected. In 1638 the wife of Luis Geronimo Fernandez de Cabrera Bobadilla y Mendoza, fourth Count of Chinchon, lay sick of an intermittent fever in the palace at Lima. Her famous cure induced Linnæus, long afterwards, to name the whole genus of quinine-yielding trees in her honour _chinchona_. The godmother of these priceless treasures of the vegetable kingdom has, therefore, some claim upon our attention.