It was soon seen, by the constant administration of many ordinary doses, that nothing was to be expected from violent or dangerous ones; as not the smallest degree of amendment ever appeared, either outwardly or inwardly, to the sensation of the patient. Mercury had no better effect. Tar-water also was tried; and if there was any thing that produced any seeming advantage, it was whey made of cow’s milk, of which he was excessively fond, and which the king ordered him to be furnished with at my desire, in any quantity he pleased, during the experiment. The troubles of the times prevented further attention. Dr Storke’s cicuta, in several instances, made a perfect cure of the hanzeers improperly opened, though, in several other cases, without any apparent cause, it totally miscarried. I scarce ever observed mercury succeed in any complaint. It is not for me to attempt to explain what are the causes of these distempers. Those whose studies lead them to such investigations will do well to attach themselves, for first principles, to the difference of climate, and the abuses that obtain under them; after this, to particular circumstances in the necessaries of life, to which nature has subjected the people of these countries. Under the first, we may rank a season of six months rains, succeeded, without interval, by a cloudless sky and vertical sun; and cold nights which as immediately follow these scorching days. The earth, notwithstanding the heat of these days, is yet perpetually cold, so as to feel disagreeably to the soles of the feet; partly owing to the six months rains, when no sun appears, and partly to the perpetual equality of nights and days; the thinnest of the cloathing in the better sort, (a muslin shirt) while the others are naked, and sleep in this manner exposed, without covering in the cold nights, after the violent perspiration during the sultry day. These may be reckoned imprudences, while the constant use of stagnant putrid water for four months of the year, and the quantity of salt with which the soil of those countries is impregnated, may be circumstances less conducive to health; to which, however, they have been for ever subject by nature. It will be very reasonably expected, that, after this unfavourable account of the climate, and the uncertainty of remedies for these frequent and terrible diseases, I should say something of the regimen proper to be observed there, in order to prevent what it seems so doubtful whether we can ever cure.