Why then do we take the long and disagreeable route to our object by giving Iodide? Thyroid feeding acts here just as it does in myxœdema. We have to take into consideration the comparative failure of the other endocrine glands, but that only adds to the charm and attractiveness of the problem. The suprarenal and the pituitary are the most important, but one must not neglect the sexual glands. I feel strongly that thyroid treatment alone or in combination is the rational method to adopt in sclerosis: personal experience confirms this every day. We purposely side-track the worn-out thyroid of sclerosis and senility, and, by thyroid feeding, restore to a great extent the whole endocrine harmony, thus giving a new tone and stimulus to existence. We shall have to use more or less thyroid feeding for the remainder of life, but we must show our patients that it is not a medicine but a necessary food. As in myxœdema, so in sclerosis, thyroid feeding is the only means, as yet known, of producing absorption of those thickenings that characterize both diseases. I have had lately the opportunity of watching and treating a thorough case of myxœdema in a lady about forty years of age, a very intelligent and educated woman. She weighs her symptoms and knows exactly when she needs more or less thyroid; she judges by her head feelings, vertigo, the sense of fatigue, etc., and by her hair falling out. But thyroid in sufficient doses produces a quick, irritable heart action; this she can quiet by taking suprarenal extract. Under sufficient thyroid her blood pressure comes down to normal and the suprarenal does not raise it. With this balanced combination she can lead a useful and enjoyable life. The same thing happens more or less in later life, where there is high pressure and other signs of arterial thickening. Suprarenal by the mouth seems to me to have the power of raising low pressures to the normal--a most valuable property in the asthenia of pneumonia and diphtheria--but there comes in some check action which prevents its causing hypertension. Dr. Sajous, the well-known scientific physician of America, at the annual meeting of the American Therapeutic Society in May 1920, said: “With regard to the adrenals, in his opinion, clinical experience with the human subject did not bear out the statements of physiologists that therapeutic doses of adrenalin had any inhibitory effects on the functions of the gastro-intestinal canal; in fact, the effect was quite the opposite. The supposed blood-pressure raising power of adrenalin also proved misleading; indeed, one of his workers found that, if there was one thing that adrenalin did not do, it was to raise blood pressure.”