The first thing was to make out precisely and clearly what was the nature of this substance, this apparently mere scum and mud that we call yeast. And that was first commenced seriously by a wonderful old Dutchman of the name of Leeuwenhoek, who lived some two hundred years ago, and who was the first person to invent thoroughly trustworthy microscopes of high powers. Now, Leeuwenhoek went to work upon this yeast mud, and by applying to it high powers of the microscope, he discovered that it was no mere mud such as you might at first suppose, but that it was a substance made up of an enormous multitude of minute grains, each of which had just as definite a form as if it were a grain of corn, although it was vastly smaller, the largest of these not being more than the two-thousandth of an inch in diameter; while, as you know, a grain of corn is a large thing, and the very smallest of these particles were not more than the seven-thousandth of an inch in diameter. Leeuwenhoek saw that this muddy stuff was in reality a liquid, in which there were floating this immense number of definitely shaped particles, all aggregated in heaps and lumps and some of them separate. That discovery remained, so to speak, dormant for fully a century, and then the question was taken up by a French discoverer, who, paying great attention and having the advantage of better instruments than Leeuwenhoek had, watched these things and made the astounding discovery that they were bodies which were constantly being reproduced and growing; than when one of these rounded bodies was once formed and had grown to its full size, it immediately began to give off a little bud from one side, and then that bud grew out until it had attained the full size of the first, and that, in this way, the yeast particle was undergoing a process of multiplication by budding, just as effectual and just as complete as the process of multiplication of a plant by budding; and thus this Frenchman, Cagniard de la Tour, arrived at the conclusion--very creditable to his sagacity, and which has been confirmed by every observation and reasoning since--that this apparently muddy refuse was neither more nor less than a mass of plants, of minute living plants, growing and multiplying in the sugary fluid in which the yeast is formed. And from that time forth we have known this substance which forms the scum and the lees as the yeast plant; and it has received a scientific name--which I may use without thinking of it, and which I will therefore give you--namely, "Torula." Well, this was a capital discovery. The next thing to do was to make out how this torula was related to the other plants. I won't weary you with the whole course of investigation, but I may sum up its results, and they are these--that the torula is a particular kind of a fungus, a particular state rather, of a fungus or mould. There are many moulds which under certain conditions give rise to this torula condition, to a substance which is