So much by way of general introduction to the subject on which I have to speak to-night. What I have hitherto stated is simply what we may call common knowledge, which everybody may acquaint himself with. And you know that what we call scientific knowledge is not any kind of conjuration, as people sometimes suppose, but it is simply the application of the same principles of common sense that we apply to common knowledge, carried out, if I may so speak, to knowledge which is uncommon. And all that we know now of this substance, yeast, and all the very strange issues to which that knowledge has led us, have simply come out of the inveterate habit, and a very fortunate habit for the human race it is, which scientific men have of not being content until they have routed out all the different chains and connections of apparently simple phenomena, until they have taken them to pieces and understood the conditions upon which they depend. I will try to point out to you now what has happened in consequence of endeavouring to apply this process of "analysis," as we call it, this teazing out of an apparently simple fact into all the little facts of which it is made up, to the ascertained facts relating to the barm or the yeast; secondly, what has come of the attempt to ascertain distinctly what is the nature of the products which are produced by fermentation; then what has come of the attempt to understand the relation between the yeast and the products; and lastly, what very curious side issues if I may so call them--have branched out in the course of this inquiry, which has now occupied somewhere about two centuries.