[45:2] The English Malady, p. 330-331. I have run my eye over Cheyne's "Natural Method of Curing Diseases of the Body and Mind," 1742, 8vo,--the only work I am aware of his having published subsequently to the date of Hume's letter, but I have found in it no trace of a reference to Hume's case. Cheyne's works are perhaps better known to the public in general, than any medical books of the same period, and their curious discursive contents amply repay perusal. Their science is of course held to be completely superseded, but the unscientific reader cannot help thinking that there is much sagacious good counsel in his advice, notwithstanding the eccentric garrulity with which it is uttered. His account of his own experiences, in experimenting on himself, is the most interesting department of his medical observations. He describes every thing with a sort of rude eloquence, infinitely more pleasing to an ordinary reader than scientific precision; and the recklessness with which he appears to have submitted his own carcass to the most violent changes of regimen, inclines one to think that he had applied towards it the _fiat experimentum in compore vili_. He tells us that he was disposed to "corpulence by the whole race of one side" of his family. In the quotation given above, he represents himself as having been studious in his youth. He began to practise his profession in London, of which he says--"The number of fires, sulphurous and bituminous; the vast expense of tallow and foetid oil in candles and lamps, under and above ground; the clouds of stinking breaths and perspiration, not to mention the ordure of so many diseased, both intelligent and unintelligent animals; the crowded churches, churchyards, and burying places, with putrifying bodies, the sinks, butcher houses, stables, dunghills, and the necessary stagnation, fermentation, and mixture of all variety of all kinds of atoms, are more than sufficient to putrify, poison, and infect the air, for twenty miles round it." Having come from the fresh air of the country into so hopeful an atmosphere, he seems to have resolved that his habit of living should be an equally great contrast to his previous studious abstinence. "Upon my coming to London, I all of a sudden changed my whole manner of living. I found the bottle-companions, the younger gentry, and free-livers, to be the most easy of access, and most quickly susceptible of friendship and acquaintance,--nothing being necessary for that purpose but to be able to eat lustily, and swallow down much liquor; and being naturally of a large size, a cheerful temper, and tolerable lively imagination; and having, in my country retirement, laid in store of ideas and facts,--by these qualifications I soon became caressed by them, and grew daily in bulk, and in friendship with these gay gentlemen and their acquaintances. I was tempted to continue this course, no doubt, from a liking, as well as to force a trade, which method I had