In January, 1823, Margaret was married to the Rev. John Breckinridge, and returned with him to Kentucky, his native State, in the spring of the same year. In consequence of a call which her husband received, to a church in Kentucky, (which he accepted,) they were soon after this settled in Lexington. Her departure from her early home was her first real trial. For although, through the course of several months, she had taken a prospective view of this arrangement, with much buoyancy of spirits, as the time approached, every circumstance connected with a separation from all the associations of her childhood and youth, seemed to produce a new and deeper impression, and seven or eight hundred miles appeared at length, as almost an interminable space. The sadness which irresistibly overspread her countenance, convinced her friends that when, in view of Mr. Breckinridge's first destination, she had given herself unreservedly to a foreign mission, she, like many others, little knew her own heart, and all the sacrifices which such a destination involved. And when it was seen expedient that this intention should be relinquished by him, for a plan more eligible in the view of his fathers in the ministry, a release from this more enduring trial, formed no small part of the considerations which assisted in making her submissively bow to one so much more lenient. And indeed, she had reason to say, that goodness and mercy had followed her at every step. For this very trial which sobered her countenance, made her heart better, and prepared the way for deeper self-examination, and probably more fervent prayer; and the result was, that with a trembling confidence she united herself with her husband's church in Lexington, a few months after he took charge of it. From her letters, after this event, we learned that her connexion with the church took place at the same time--it is thought on the same day--in which her sister Elizabeth, having been delivered from the many doubts which had clouded _her_ mind, made a profession of religion in the church in Princeton. This co-incidence in providence, having occurred without any mutual intercourse or understanding on the subject, seemed so consistent with the plans of Him who "sees the end from the beginning," and who, from their first serious impressions, appeared to have united the lines of their experience until they ended in one gracious result, that it did much to confirm their friends in the hope, that a good "work was begun in them which should be carried on." They felt constrained to say, "It is the Lord's doings and wonderful in our eyes."