RACE.—Cancer has been observed in every race, though the proportion of cases is observed to vary greatly among different peoples; but it is interesting to note that it is universally agreed by those that have studied the subject that the difference in frequency relates very largely to the degree of civilization involved. The blond Nordic race, however, seems to be more susceptible to the disease than the darker races, originally of Asiatic origin; and it is the former who have pushed forward modern civilization, with all its errors of life. Thus cancer is everywhere reported to be rare, and sometimes almost absent, in primitive, uncivilized peoples, but it has been repeatedly observed, in many localities, that as these same people mix with Europeans and adopt their diet and mode of life, cancer is sure to increase, until its frequency often about equals that in their highly civilized neighbors. I went over this matter pretty fully in my former lectures and cannot dwell on it now, or give examples. I can only emphasize the fact that this furnishes a strong support to the contention that cancer depends upon disorders of metabolism, which are certainly increasing under the various elements which compose what is called advanced civilization. CLIMATE AND LOCALITY.—There is no evidence to prove that climate has any influence in the production of cancer, nor is it affected by locality; the disease occurs in hot, warm, temperate, and cold climates, and in every possible location on the earth. But it is undoubtedly most prevalent in temperate regions, for the reason that it is in these that modern civilization, with all its faults and foibles, is most highly developed. The subject of the topical distribution of cancer, or its occurrence in certain regions, has been the subject of much controversy in England and France especially, and to read certain statements one would be inclined to believe that certain telluric conditions were of influence in its production, as along certain water courses, etc. But a more careful analysis of all these statements shows that such elements can act only as contributing causes, as, for instance, through a rheumatic influence, which is known to be found in so many cancer patients.