If this theoretic conception was correct, Pasteur might expect to find that all the substances in which M. Biot had observed the power of rotating the plane of polarisation would possess the crystalline dissymmetry revealed by the absence of superposability. The result was in great part conformable to those previsions. The substances which acted upon polarised light, as liquids or solutions, were generally found by Pasteur to produce dissymmetric crystals. Some of them, however, notwithstanding their power of crystallisation, exhibited, when crystallised, no dissymmetric face. This difficulty did not deter Pasteur. It gave him, on the contrary, the opportunity of showing that when a theory had in so many cases proved itself correct, an apparent objection must not be assumed insuperable without first sounding it to the bottom. May it not be, he reasoned, that the absence of dissymmetry in substances which have the molecular rotatory power is not an accident; and may it not be possible, by changing the conditions of the crystallisation, to make the dissymmetry appear? Then, in order to modify the crystalline forms of substances which did not show themselves to be spontaneously dissymmetrical, Pasteur employed a method which had been often tried before, though its principles could not be explained or its effects foreseen. In imitation of Romé de Lisle, Leblanc, and Beudant, he varied the nature of his solvents; he introduced into the solution, sometimes an excess of acid or of base, sometimes foreign matters incapable of acting chemically upon those which were to be modified; he even employed sometimes impure mother liquids. On each occasion new facets were thus produced, and these new facets showed the kind of dissymmetry which the optical character demanded. Although he had to limit his researches to those substances which, by their ready crystallisation and the beauty of their forms, lent themselves best to this class of proofs, the results were so far in accord with the previsions of theory, that no reasonable doubt could exist as to the necessary correlation between dissymmetry and the power to deviate polarised light. * * * * *