Piebald rats and selection : $b An experimental test of the effectiveness of selection and of the theory of gametic purity in Mendelian crossesCastle, William E. (William Ernest)
Science
Piebald rats and selection : $b An experimental test of the effectiveness of selection and of the theory of gametic purity in Mendelian crosses
Castle, William E. (William Ernest)
Heredity
In Table 15 have been brought together for comparison the means of the
several horizontal rows of Tables 1 to 13. By examining the vertical
columns of Table 15 the mean grade of the offspring of parents of a
particular grade in any generation may be compared at a glance with that
of parents of the same grade in any other generation. By running the
eye down the columns, it will be observed that the mean grade of the
offspring tends to increase upon repeated selection. Thus parents of
grade 3.75 appear first in generation 4, the grade of their offspring
being 2.75; the offspring of such parents in subsequent generations grade
in order, 3.07, 3.22, 3.35, 3.49, 3.50, 3.69, 3.75, and 3.83 (twelfth
generation not complete). The difference between parents and offspring in
this series grows less and less and finally disappears altogether. If the
grade of 3.75 parents in this series is compared with the grade of _all_
offspring in the corresponding generations we have the following:
TABLE A.
+-----------+-----------------------+------------------------+
|Generation.| Mean of offspring of | Mean of offspring of |
| | 3.75 parents. | all parents. |
+-----------+-----------------------+------------------------+
| 4 | 2.75 | 2.73 |
| 5 | 3.07 | 2.90 |
| 6 | 3.22 | 3.11 |
| 7 | 3.35 | 3.20 |
| 8 | 3.49 | 3.48 |
| 9 | 3.50 | 3.54 |
| 10 | 3.69 | 3.73 |
| 11 | 3.75 | 3.77 |
| 12 | 3.83 (35 individuals)| 3.94 (590 individuals)|
+-----------+-----------------------+------------------------+
In generation 4 the 3.75 parents represented the most advanced
individuals of the series, a whole grade in advance of the general
average of the race. Their offspring showed a correspondingly large
regression. The general average of the race steadily advanced in later
generations until in generation 11 it equaled that of the 3.75 parents;
then the regression vanished. In the following generation, 12 (which
is still incomplete, but in which the average of the offspring thus
far is 3.94), the 3.75 group of parents, which are now _below_ the
average of the race, actually produce offspring of higher grade than
themselves, viz, 3.83. It will thus be seen that the _regression is
uniformly toward the mean of the race and changes its direction when
that mean changes its position with reference to a particular grade of
parents_. This conclusion is supported by other columns of Table 15, but
is best illustrated by this particular case because here the selection
has extended over a greater number of generations than elsewhere in the
series.
Public-domain text, read in full here on John Shaqi.
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