In the Wisconsin Agricultural Experimental Station, an experiment was conducted for fourteen days on the effect of ample and deficient ventilation on a herd of cows. The stable was chiefly underground and had two large ventilators which could be opened or closed at will. The food eaten, the water drunk, the milk produced, and weight of the cows were recorded each day. For a part of the time the cows were kept continuously in the stable with all openings closed, and then the ventilators were opened, the alternate conditions being repeated at intervals of four days. The amount of food consumed was practically the same under both conditions. The quantity of milk given was greater with good ventilation. The chief difference was in the amount of water consumed, since with the insufficient ventilation the cows drank on the average 11.4 pounds more water each, daily, and yet lost in weight 10.7 pounds at the end of each two-day period. Examination of the animals themselves also showed that a rash had developed on their bodies which could be felt by the hand and which was apparently very irritating, since it was so rubbed by the animals as to cause the surface to bleed. The evident teaching of the experiment is that under conditions of poor ventilation, it was impossible for the lungs to remove waste products to as great an extent as usual, and, therefore, the demand for additional water was felt in order to stimulate greater action on the part of the kidneys to care for these waste products. That this was not a successful substitute was shown by the loss of weight in the animals, and by the irritation of the skin which evidently was trying to eliminate some of the remaining impurities through its surface. _Modifying circumstances._ Fortunately for mankind, it has not been customary, nor even possible, to build dwellings or stables approaching the air-tightness of a fruit jar. Air has great power of penetration, particularly when in motion, and a wind will blow air through wooden walls, and even through brick walls, in considerable quantity. It is practically impossible to build window casings and door frames so that cracks do not exist, through which air may find its way. When, however, in the wintertime, storm windows have been put on, or when, as occasionally happens, to keep out drafts, strips of paper are pasted carefully around all window casings, or when rubber weather strips are nailed tight against the windows and doors, conditions are obtained which resemble the mason fruit jar, and under those conditions, a person living continuously in such a room is experimenting on himself as Professor King did with the candle.