The total number of students in the Medical School of Transylvania during the term of its existence was, as far as can now be ascertained, more than six thousand four hundred (6,456); the total number of its medical graduates eighteen hundred and eighty-one (1,881).[45] During the late civil war the commodious Medical Hall of Transylvania, built in 1839 by the munificence of the city of Lexington, and which had been seized by the United States Government for use as a United States General Hospital, was destroyed by fire while occupied for that purpose.[46] But the medical library,[47] apparatus and museum, etc., were mainly preserved, and are now in the custody of the Curators of Kentucky University, with which institution old Transylvania University was consolidated in 1865, "all the trusts and conditions" of her property being preserved in the Act of Consolidation. The Medical Department may yet be resuscitated when in the course of events our city again becomes an eligible site for modern medical instruction, and when special means can be obtained properly to equip and re-establish it on a basis suited to the existing times. The gradual decline of this school, like its rapid rise, was due greatly to the changing conditions of the country. When, shortly after 1812, steamboat navigation began to manifest its superiority and influence on the channels of commerce, population and business deserted measurably the interior routes and locations and transferred themselves to the river valleys and neighborhoods. Gradually during this change--notwithstanding the talents, ability, and fame of our Brown, Dudley, Caldwell, Cooke, Short, Yandell, Bartlett, Mitchell, Smith, and others, and the generous support of the city--the school declined; more especially because of the establishment of rival colleges at more eligible points, in growing and populous cities. Lexington lost its pre-eminence as the "_Metropolis of the Western Country_," and Cincinnati, Louisville, St. Louis, and other places which had been villages supplied with her manufactures, rapidly became great cities; while she declined from a population of about eight thousand in 1814, down to a little over four thousand in 1820, with an immense loss to her citizens in the value of her property and the destruction of her industries. In this year (1820) the population of Cincinnati, which in 1810 had been only two thousand, three hundred and twenty, had risen to nine thousand, six hundred and forty-four; and in 1830, when the population of Lexington was yet only five thousand, six hundred and sixty-two, that of Cincinnati was twenty-four thousand, eight hundred and thirty-one. When the present writer came to Lexington in 1832 the population had remained nearly the same, and an era of decrepitude and decline of all her industries still prevailed. Lexington had not yet finished her first railroad.