I need not repeat that water in some form is necessary to the production of that peculiar vegetable decomposition which is the source of this poison; and so true is this, that even in the tropical regions, the diseases from this cause are nearly unknown in districts of peculiar dryness, as they are in the drier seasons of those countries. Thus, for example, Egypt is free from such fevers, except at the period of the subsidence of the Nile, unless where, as at Damietta, the cultivation of rice is pursued; and the same is true of Mesopotamia very remarkably: and if I dare not extend these illustrations, I must remark that in all these cases, the action of moisture is twofold, inasmuch as it not only accelerates vegetable decomposition, but renders the atmosphere a fitter conductor of this poison. Taking these two causes of the increase in the quantity and in the action of malaria, we can explain many particulars which relate to its power in producing diseases: and as the knowledge of these is important as far as relates to the main object of this paper, prevention, it becomes necessary to explain them at a little more length. As to season, the simplest case is that of the intertropical climates; and Africa offers the plainest instance among the [p041] whole. There, the malaria and the fever commence at the moment the rain falls; diminishing as the ground becomes thoroughly wetted, and recommencing as it dries. The explanation of all this ought to be obvious; and the same analogy governs all the hotter climates, as, though less conspicuously, it does our own. Hence we explain, both as to our spring and our autumn, the effects of heat following rain, or the reverse, and the diseases which are consequent on those changes: and thus it is, though more remarkably, in Italy, that a rainy autumn increases the number and severity of fevers; or, if the summer has been unusually dry, that they often do not appear till the commencement of the autumnal, or even the winter rains. And hence, also, even with us, the occurrence of a single rainy day or week, in the midst of the heats, will produce fevers; while the effect of this influence is such, that should there even be an entire rainy summer, and the subsequent one be hot and dry, this will be attended by an unusual production of malaria and disease.