In February 1375, Catherine left Siena for Pisa, charged with negotiations on the Pope's behalf with the latter republic. Here she stayed, with a band of her disciples, some months, so enfeebled with continual ecstasies that they thought her at the point of death. Here, on the Fourth Sunday of Lent, she is said to have received the Stigmata--the wounds of Christ's Passion--in her body, in the little church of Santa Cristina on the Lungarno. Be this as it may, a new epoch in her life begins at this date--the epoch of her two great struggles for the Church and for Italy. Since Clement V. removed the papal chair to France in 1305, the Popes had resided at Avignon. Their court had become a scandal to Christendom; Rome was abandoned to ruin and ravage. Previously to this date, the temporal sovereignty of the Popes had been little more than a nominal suzerainty over the cities of the Papal States, many of which were either swayed by petty despots or governed themselves as free republics. But now things were changing. While the Roman Pontiffs remained beyond the Alps, their legates were attempting to fuse these various elements into a modern State. At the head of foreign mercenaries they were subjugating city after city, and building fortresses to secure their hold. Florence, though forming no part of the Papal States, saw her liberties threatened. The refusal of the Legate of Bologna, although he had letters to the contrary from the Pope, to allow corn to be sent from his province into Tuscany in time of famine--followed, as it was, by the appearance of Hawkwood in the territories of the Republic--precipitated matters. War broke out in the latter part of 1375. The Florentines appointed a new magistracy, the Eight of the War, to carry it on, and sent a banner, upon which was _Libertas_ in white letters on a red field, round to all the cities, offering aid in men and money to any who would rise against the Church. Città di Castello began; Perugia followed; and in a few days all central Italy was in arms against the Temporal Power. "It seemed," wrote a contemporary, "that the Papal States were like a wall built without mortar; when one stone was taken away, almost all the rest fell in ruins." The republics of Siena and Arezzo promptly entered the league; Pisa and Lucca wavered. Conciliatory overtures from the Pope, who offered to leave Città di Castello and Perugia in liberty and to make further concessions for the sake of peace, were cut short by the expulsion of the Papal Legate from Bologna. Florence was solemnly placed under the interdict, and an army of ferocious Breton soldiers taken into the pay of the Church, under the command of the Cardinal Robert of Geneva, for the reconquest of the Papal States.